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The prespecified selection criteria included: (1) RCTs reporting desired cardiovascular or renal outcomes

Target specificity and off-target effects represent other challenges

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Here, we review the role of GLP-1 and the actions of associated therapies on glucose metabolism, the gutrenal axis, classical renal risk factors, and renal end points in randomized controlled trials of GLP-1 receptor agonists and DPP-4 inhibitors in patients with T2DM

For intramuscular and intravenous administration